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Isaac NEWHOUSE II
Martha McCULLOCH
Winifred SANDIFORD
Husband:  Isaac NEWHAUSE / NEWHOUSE II
Birth:  ca. 1775, Fauquier Co., VA
Death apparently:  1820-30, presumably in Fayette Co., IN
Father:  Isaac NEWHOUSE I
Mother:  Catharine VAN PELT
Marriage-1:  21 Jun 1798, Washington Co., VA
Wife-1:  Martha McCULLOCK / McCULLOCH
Birth:  ca. 1779
Death(?):  1810-20 (if so, closer to 1810), presumably in Washington Co., VA

It's possible that Martha didn't die 1810-20, but was instead divorced from Isaac.  If so, it's easier to explain why her children did not move to Indiana with Isaac, but stayed in Virginia with her.

Marriage-2:  12 Sep 1820, Fayette Co., IN
Wife-2:  Wineferd SANDEFER / Winifred SANDIFORD
Children with Martha McCULLOCH born in Washington Co., VA:
1.  Isaac NEWHOUSE III, b. 1801/2; m1. ca. 1829, Sullivan Co., TN, Nancy JAMES
2.  John NEWHOUSE, b. 1806/7; m1. 29 Aug 1827, Washington Co., VA, Nancy JAMERSON
3.  Mary M. NEWHOUSE, b. 1809/9; m. 9 Jul 1829, Washington Co., VA, James CLARK

For John and Mary to have married in Washington Co., VA, Isaac II must have left these children of his first marriage behind when he moved to Indiana.  As for Isaac III, I can only surmise that he stayed behind, too, then made his own way to Sullivan Co., TN, as an adult.

Children with Winifred SANDIFORD:
-
Keywords for search engines:  genealogy; USA, US, United States, Indiana, Virginia

Sources (n.b., until 1832, Wythe Co. was adjacent to Washington Co.; Sullivan Co. is adjacent to Hawkins Co.):

1a.  Jordan R. Dodd, ed.  1993.  Virginia Marriages:  Early to 1850.  Liahona Research, Orem, UT (Broderbund CD-229):
Newhouse, Isaac Mccullock, Martha 21 Jun 1798 Washington Co.

1b.  Lewis Preston Summers.  1929.  Annals of Southwest Virginia, 1769-1800.  Abingdon, VA (reprinted 1970 by Genealogical Publ. C., Baltimore, MD; online at Ancestry.com):
Part 2 p. 1267 WASHINGTON COUNTY MARRIAGES
DATE GROOM BRIDE MINISTER
1798, June 21 Newhouse, Isaac Martha McCullock Charles Cummings

1c.  Jordan R. Dodd, ed.  1993.  Illinois/Indiana Marriages:  Early to 1850.  Liahona Research, Orem, UT (Broderbund CD-228):
Newhouse, Isaac Sandefer, Wineferd 12 Sep 1820 Fayette Co.

2.  1800 Census Index/Images (online at Ancestry.com):  the 1800 Virginia census was destroyed.

3.  The 1806 Washington County, Virginia, Personal Property Tax List (online at newrivernotes.com; transcribed by Jeffery C. Weaver):
Name Whites Blacks<16 Blacks>16 Horses
Newhouse, Isaac 1 - - 2

4.  1810 Census Index/Images (online at Ancestry.com, Image #16 of 73 indexed "Newham"; extracted by Diana Gale Matthiesen):¤
1810 VA Washington Co. Roll 71 p. 208B/704 Ln. 25 Isaac Newhouse 20010-10010-00
These data indicate:
No. & Sex Age Class Therefore Born Individuals Inferred
2 males 9 or under 1800-1810 = John (b. 1806/7)
= Isaac III (b. 1801/2)
1 male 26-44 1765-1784 = Isaac II (b. ca. 1775)
1 female 9 or under 1800-1810 = Mary (b. 1808/9)
1 female 26-44 1765-1784 = Martha (b. ca. 1779)

5.  1820 Census Index/Images (online at Ancestry.com):  can't find, which supports that our subject is a widower living with another family (i.e., is not a head-of-household).  He's presumably in Fayette Co., IN, because that's where three of his siblings are living (viz., John NEWHOUSE, James NEWHOUSE, and Mary (NEWHOUSE) SERGEANT) and that's where he remarries on 12 Sep 1820.  [John and James are the only NEWHOUSEs in all of Indiana.]

6.  1830 Census Index/Images (online at Ancestry.com):  The four Isaac NEWHOUSEs in the U.S. Census are all otherwise accounted for, so it appears out subject is deceased.  Our subject's son, Isaac III, is married and living in Sullivan Co., TN.  Our subject's son, John NEWHOUSE, is married and living in Washington Co., VA.  Our subject's daughter, Mary, is married and living in Washington Co., VA, with her husband, James CLARK

7.  LDS.  Family Search: Internet Genealogy Service: Pedigree Resource File (index to CDs, online at FamilySearch.org).

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