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Conrad NULL
Ms. __?__
Margaret CUPP
Mrs. Catharine (__?__) DOWNHOUSE
Husband:  Conrad NULL / NOLL
Birth:  1780
Death:  bef. 18 Sep 1848
Marriage-1:
Wife-1:  Ms. __?__
Based on the 1830 Census (see below), it appears Conrad had a wife before Margaret, and given Conrad's age, we would expect that he did.  Either that or the 1826 marriage date really is 1816.
Marriage-2:  29 Aug 1826, Augusta Co., VA, but said to be in 1816
Wife-2:  Margaret "Peggy" CUPP
Birth:  20 Apr 1789, Augusta Co., VA
Death:  1840-42, Perry Co., OH
Occupation:  homemaker
Father:  Marcus CUPP
Mother:  Margaretha __?__
Marriage-3:  12 Apr 1842, Perry Co., OH
Wife-3:  Catharine __?__
Birth:  1806/7, OH
Death: aft. 18 Sep 1848
Occupation:  homemaker
Other Spouse:  m1. Mr. DOWNHOUSE/DOWNHOUR/DOWNER
Other Children:
1.  Bernard DOWNHOUSE, b. 1833/4, OH
2.  Henry DOWNHOUSE, b. 1838/9, OH
Child with Wife-1:
1.  (Son? A) NULL, b. 1820-25
Children with Margaret CUPP:
apparently none
Children with Catharine:
2.  Anna/Ann Catherine NULL, b. 1842/3
3.  Susannah "Susan" NULL, b. 1844/5
4.  Lucinda NULL, b. 1848


Sources:

1a.  Jordan R. Dodd, ed.  1993.  Virginia Marriages:  Early to 1850.  Liahona Research, Orem, UT (Broderbund CD-229):
Noll, Conrad Cupp, Peggy Aug 29, 1826 Augusta Co.
There is reason to believe this transcription is a typo and that they were married in 1816, not 1826.

1b.  LDS.  Family Search: Internet Genealogy Service: IGI - International Genealogical Index (online at FamilySearch.org).
Conrad NULL
Spouse: Catharine DOWNHOUR
Marriage: 12 Apr 1842, Perry, Ohio
Source: patron submission

2.  Census Index:  U.S. Selected Counties, 1820 (Broderbund CD-314):  can't find.  (He's not either of the C. NULLs in OH.)

3.  1830 Census Index and Digital Images (online at Ancestry.com; Image #3 of 20; extracted by Diana Gale Matthiesen):¤•
1830 OH Perry Co. Thorn Twp. p. 417 Ln. 14 Conrad Null 010 001 010 - 000 000 100
These data indicate:
No. & Sex  Age Class Therefore Born Individuals Inferred
1 male 5-9 1820-1825 = Son A
1 male 30-39 1790-1800 = ?
1 male 50-59 1770-1780 = Conrad (b. 1780)
1 female 40-49 1780-1790 = Margaret (b. 1789) 
"Son A" was born before Margaret and Conrad married, so it appears Conrad had an earlier wife — unless their marriage date is wrong.

4.  1840 Census Index and Digital Images (online at Ancestry.com; Image #5-6 of 20; extracted by Diana Gale Matthiesen):¤•
1840 OH Perry Co. Thorn Twp. pp. 58B-59A Ln. 1 Coonrod Null 000 100 010 - 000 000 010 0200000
These data indicate:
No. & Sex Age Class Therefore Born Individuals Inferred
1 male 15-19 1820-1825 = Son A
1 male 50-59 1780-1790 = Conrad (b. 1780)
female 50-59 1780-1790 = Margaret (b. 1789)
2 persons engaged in agriculture

5.  1850 Census Index/Images (online at Ancestry.com; Image #24 of 44):  Thorn Twp., Division No. 117, Perry Co., OH, p. 408B/816, 1258/1258, enumerated 16 Oct 1850 (extracted by Diana Gale Matthiesen):
Catharine Null 43 F     Ohi
Bernard Downhouse 16 M Farmer 800 Ohi
Henry       " 11 M     do
Ann C Null  7 F     do
Susan   "  5 F     do
Luzinda "  1 F     do
Bernard and Henry must be Catharine's children by her first marriage.

6.  Rosalie Hartinger, contributor.  1989.  "Perry County, Ohio — Will Abstracts 1818-1851."  Vol. II, pp. 353-381, in Ruth Bowers & Anita Short.  Gateway to the West.  2 vols. Genealogical Publ. Co., Baltimore, MD (Broderbund CD-175).  On p. 372:
NULL, Conrad - dated 9-18-1848.  Wife, Catherine.  Mentions deceased wife, Margaret.  Children: Anna Catherine, Susannah and Lucinda.  Executors: John and Samuel Cupp.  Witnesses:  Emanuel Fisher and Wm. Dempsey. (257)

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