Anna Margaretha was the second wife of Hans Nicolaus EISENHAUER.  He was born 1691, probably in Eiterbach, about eight miles from Heidelberg, Germany, a son of Hans Peter EISENHAUER and his second wife, Anna Catharina MILDENBERGER. Anna Margaretha & Hans Nicholas were married about 1725.  Hans Nicolaus had two children by his first wife (name unknown) and three with Anna Margaretha.

Anna Margaretha had a brother, Friedrich STRUBEL, who had emigrated to Pennsylvania, arriving in Philadelphia on 11 Sep 1731.  He settled in Lebanon (then Lancaster) Co., and there he prospered for ten years, at which time he returned to Hessen, Germany, to find a wife.  He was married on 18 April 1741 at Neuenheim, across the Neckar River from Heidelberg, a wedding attended by his sister Anna Margaretha and her husband, who shortly thereafter followed Friedrich to Pennsylvania.

Economic conditions in the Odenwald (the wooded uplands north of Heidelberg and south of Darmstadt), had been bad for nearly a century.  The Thirty Year's War (1618-1648) had only made things worse, with mercenary soldiers pilaging and looting wantonly and the Odenwald suffering perhaps the worst.  A deadly plague followed the war.  Among the survivors of this time of trial was Hans EISENHAUER (b. ca. 1600), father of Hans Peter EISENHAUER (b. ca. 1650).

Between 1674 and 1677, the Odenwald was overrun by French and Imperialist troops, forcing villagers to flee into the forest where many died of hunger and cold. Among those fleeing were Hans Peter & Anna Catharina (MILDENBERGER) EISENHAUER and their children.  Hans Peter was still living in 1700, as was his son, Hans Nicholaus.

Hans Nicholaus & Anna Margaretha (STRUBEL) EISENHAUER arrived in Philadelphia on 17 November 1741, having sailed on the Europa from Rotterdam. They settled in Bethel Twp., Lebanon (then Lancaster) Co., PA, near Anna's brother, Friedrich STRUBEL.  On 20 January 1753, just 200 years to the day before the inauguration of President EISENHOWER, Hans Nicholas had 168 acres surveyed near Fredericksburg, Bethel Twp., Lebanon (then Lancaster) Co.  The Pennsylvannia Gazette reported on 12 August 1756 that Indians had burned the log house of Hans Nicholaus EISENHAUER.

Peter EISENHAUER (b. ca. 1716) came to the U.S. in 1741 with his parents, Hans Nicholas & Anna Margaretha (STRUBEL) EISENHAUER.  He settled in Swatara Twp., Lebanon Co., and married three times, the last to Anna DISSINGER on 29 Jan 1777. Peter had at least 17 children and died in Lower Paxton Twp., Dauphin Co.  Peter's son, Frederick EISENHOWER (b. 15 Jul 1794 in PA; d. 13 Mar 1884, Abilene, KS), married Barbara MILLER in 1816.

Frederick & Barbara (MILLER) EISENHOWER had a son, Jacob Frederick EISENHOWER, who married Rebecca MATTER.  Jacob & Rebecca (MATTER) EISENHOWER were the paternal grandparents of President Dwight D. EISENHOWER.